More than 30 "pop up" brothels each week are being opened in Swindon with foreign hookers renting properties for a few days before moving on.
Wiltshire Police said that every week, as many as 40 prostitutes, most of whom are eastern European, were advertising their services in the town.
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It is the latest in a spate of reports across the country of temporary brothels, where rooms are rented for just a few days before women are swiftly moved on to evade detection.
The majority of the prostitutes are "transient", with many of the brothels thought to be linked to organised crime gangs which traffick women from Poland and Romania.
Earlier this month Devon and Cornwall police said they had discovered at least 14 "pop-up" brothels in the past six months in the seaside resort of Newquay, a popular destination for surfers as well as stag and hen parties.
Inspector Dave Meredith, Newquay's most senior police officer, said that his force expected to discover more pop-up brothels in the town this summer.
Last year police said hotels and guest houses in the Lake District were also being used as brothels.
He said: "I've never known one [a pop-up brothel] to stay more than seven days, usually quite a bit less.
"They move quickly, they book them online and they advertise their services via the internet.
"Certainly you wouldn't see anything in the local papers or women touting for business in the street. It's all web-based.
"The evidence that we have indicates that the majority in Newquay are coming from eastern Europe.
"We've got a victim-centred approach although it is an offence to operate a brothel. A lot of the women are vulnerable."
Last year police said hotels and guest houses in the Lake District were also being used as brothels, offering prostitutes during weekend stays.
Crime gangs trafficked refugees to use as illegal sex workers and block-booked hotel rooms in Barrow and across the south lakes, Cumbria police said at the time.