Weather forecasters have warned the northeast of the US of impending blizzards with as much as two feet of snow expected over the next 48 hours.
Winter storm Juno is expected to wreak havoc on cities from Baltimore to Portland in Maine, more than 500 miles to the north, reports the Telegraph.
Up to 16 states could be hit by the blizzards over the next few days.
According to USA Today, more than 3,550 flights have already been cancelled ahead of the storm.
"This could be the biggest snowstorm in the history of this city," said Mayor Bill de Blasio, New York City's mayor.
"My message for New Yorkers is prepare for something worse than we have ever seen before."
Travel will be extremely difficult and even impossible in some regions.
There is also the danger of power cuts as the majority of power line in the US are above ground.
Several inches of snow have already fallen across New England, leading to hundreds of flights being cancelled and delayed.
As of 6:15 a.m. ET, airlines had grounded 1,851 flights for Monday and another 1,707 for Tuesday, according to FlightAware.
United, the nation's second-busiest carrier, said it expected to halt all of its Tuesday operations at several of the region's busiest airports
With so many airlines and hubs affected, the storm was expected to affect air travel across the United States on Monday and Tuesday.
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