A U.S. Airways flight from Israel to Philadelphia made an emergency landing in Rome when 16 people starting vomiting and suffering from red eyes on board.
The flight from Tel Aviv was forced to land at Rome's Leonardo da Vinci airport on Saturday morning after a foul odour sickened 14 cabin crew and two passengers.
They were treated and released from a hospital in Rome when the flight landed, Fox News reports.
Martha Thomas, a spokeswoman for American Airlines, which merged with U.S. Airways last year, said: "The aircraft landed safely and all passengers were re-accommodated on other flights."
She added that American Airlines is investigating the source of the rubbery odour.
According to the Daily Mail, the odour could have been due to a malfunctioning ventilation system.
Last month, a Lufthansa flight carrying 82 passengers from Manchester to Munich made an emergency diversion to Stuttgart after the pilot smelled an 'unusual odour' in the cockpit.
The airline said the flight diverted because of "technical reasons" and confirmed the pilot had noticed a strange smell.
The flight was met by ambulances and fire trucks when it landed safely at Stuttgart.
The flight bound for Sydney was forced to turn back to Los Angeles after sinks on board leaked.
Julia Malley, a resident of Christchurch, where the plane was headed after Sydney, said the smell was "unbearable" in an interview with New Zealand radio, suggesting there was human poo flowing into the cabin.
However, Virgin denied there was leakage from the toilets onboard.
Plane diverted as 12 passengers fall sick from foul odour
Plane returns to airport after 'strange smell' causes flight attendant sickness