Neymar will undergo surgery on a fractured foot, Paris Saint-Germain have confirmed.
The Brazilian suffered a cracked metatarsal, as well as a sprained ankle, during a 3-0 Ligue 1 defeat of rivals Marseille on Sunday.
PSG coach Unai Emery initially indicated he felt Neymar would return in time to face Real Madrid in the second leg of their last-16 Champions League tie on March 6.
But with Neymar requiring surgery on his foot injury, the world's most expensive player will now face a substantial period on the sidelines.
"At the end of the protocol initially planned for three days of care, a report was made today jointly by the medical staff of Paris Saint-Germain and that of the Brazilian national team," a PSG statement said on Wednesday.
"At the end of this report and in agreement with the player, it was decided to favour the surgical option.
"Neymar will be operated at the end of the week in Brazil by Dr Rodrigo Lasmar, accompanied on site by Professor Saillant (Paris Saint-Germain)."