The uncapped Jordan Larmour has been joined by recent newcomers Chris Farrell and Bundee Aki in an Ireland squad missing, as expected, Garry Ringrose for the first two matches of the Six Nations.
An ankle injury suffered playing for Leinster in the Pro14 this month means centre Ringrose will not be involved for the Tests away to France and at home to Italy to open the tournament.
Finlay Bealham, Jamie Heaslip, Sean O'Brien, Rhys Ruddock, Tommy O'Donnell, Luke Marshall, Jared Payne, Craig Gilroy and Niall Scannell are also all sidelined, although the latter is due to return to action soon, according to a statement released by Irish Rugby.
"It's been great to witness some quality performances from provincial teams over the last seven weeks of European and derby matches, with a number of players performing well," Ireland coach Joe Schmidt said in the statement.
"There were some very tight decisions but it's great to see some competitive depth in a number of positions."
Larmour, a 20-year-old Leinster wing, could follow in the footsteps of Farrell and Aki, who play at centre for Munster and Connacht respectively and made their debuts in the November internationals series.
Forwards: Rory Best, Jack Conan, Sean Cronin, Ultan Dillane, Tadhg Furlong, Cian Healy, Iain Henderson, Rob Herring, Dave Kilcoyne, Dan Leavy, Jack McGrath, Jordi Murphy, Peter O'Mahony, Andrew Porter, Quinn Roux, James Ryan, John Ryan, CJ Stander, Devin Toner, Josh van der Flier.
Backs: Bundee Aki, Joey Carbery, Andrew Conway, Keith Earls, Chris Farrell, Robbie Henshaw, Rob Kearney, Ian Keatley, Jordan Larmour, Kieran Marmion, Fergus McFadden, Luke McGrath, Conor Murray, Johnny Sexton, Rory Scannell, Jacob Stockdale.