Hadleigh Parkes will make his Wales debut as one of five changes for their final Test of the year against South Africa in Cardiff.
The Scarlets centre will partner Scott Williams in the middle, while scrum-half Aled Davies replaces Rhys Webb at nine.
In the forwards, Kristian Dacey and Scott Andrews come into the front row, while Cory Hill is paired with captain Alun Wyn Jones at lock.
Head coach Warren Gatland said: "Saturday is an opportunity to continue to build on what we have done so far and round off the autumn campaign with a big performance.
"We have spoken about exposing the squad to Test match rugby and this weekend is a great opportunity for Hadleigh to earn his first cap and for Aled to make his first start of the campaign.
"We have had a couple of knocks from last weekend, with Ken [Owens], Leon [Brown] and Jake [Ball] unavailable but that just provides an opportunity for Kristian, Scott and Cory to start."
Wales put up good performances in defeats to Australia and New Zealand either side of a 13-6 win over Georgia during their Autumn internationals thus far.
-- Welsh Rugby Union (@WelshRugbyUnion) November 30, 2017
Wales: Leigh Halfpenny, Hallam Amos, Scott Williams, Hadleigh Parkes, Steff Evans, Dan Biggar, Aled Davies; Rob Evans, Kristian Dacey, Scott Andrews, Cory Hill, Alun Wyn Jones, Aaron Shingler, Josh Navidi, Josh Navidi, Taulupe Faletau
Replacements: Elliot Dee, Wyn Jones, Rhodri Jones,Seb Davies, Dan Lydiate, Rhys Webb, Rhys Patchell, Owen Watkin