Warrick Gelant and Dan du Preez will make their first starts for South Africa in Saturday's Test against Wales.
Exciting Bulls winger Gelant made his Springboks debut in last week's win over Italy and is named in the starting XV on the left wing in place of Courtnall Skosan in Cardiff.
Du Preez also comes in as one of five changes to the starting line-up, taking the place of Duane Vermeulen at number eight.
There are three other changes in the forwards, with Malcolm Marx named at hooker in place of Bongi Mbonambi, Siya Kolisi returns from paternal leave to take over from Francois Louw at flanker, and Steven Kitshoff replaces the injured Tendai Mtawarira (groin) at prop.
"Warrick is an elusive runner, he used his opportunity last week and I am looking forward to see him getting a start on Saturday," head coach Allister Coetzee said.
"It is great to welcome Malcolm back, however, Bongi did a superb job against Italy and I expect the same performance from him when he comes on later in the game."
Louw and Vermeulen have returned to Bath and Toulon respectively, as the fixture takes place outside of the international window.
The #Springboks team to face @WelshRugbyUnion on Saturday has been named. In total, 11 changes to side that outplayed @Federugby last weekend. Start for @WarrickGelant and potential debuts for @LouisSchreuder and Lukhanyo Am. @FNBSA@Mtnsa@LandRover@CastleLagerSApic.twitter.com/UUpNBYia0a-- South African Rugby (@Springboks) November 30, 2017
South Africa: Andries Coetzee, Dillyn Leyds, Jesse Kriel, Francois Venter, Warrick Gelant, Handre Pollard, Ross Cronje; Steven Kitshoff, Malcolm Marx, Wilco Louw, Eben Etzebeth (captain), Lood de Jager, Siya Kolisi, Pieter-Steph du Toit, Dan du Preez,
Replacements: Bongi Mbonambi, Trevor Nyakane, Ruan Dreyer, Oupa Mohoje, Uzair Cassiem, Louis Schreuder, Elton Jantjies, Lukhanyo Am