Mathieu Bastareaud will make his first France appearance for over two years and the uncapped Anthony Belleau will start at fly-half against New Zealand on Saturday.
Bastareaud has not played for his country since the Rugby World Cup quarter-final against the All Blacks in October 2015, but will start versus the same opponents at Stade de France this weekend.
Belleau is preferred to Francois Trinh-Duc in the absence of Camille Lopez for depleted Les Bleus and will form a young half-back pairing with Antoine Dupont, who gets the nod over Baptiste Serin.
Lock Paul Gabrillagues and back-row Judicael Cancoriet will also make their debuts against the world champions in Paris.
Wing Teddy Thomas returns to the side, having been absent since February 2016.
France: Nans Ducuing, Teddy Thomas, Geoffrey Doumayrou, Mathieu Bastareaud, Yoann Huget, Anthony Belleau, Antoine Dupont; Jefferson Poirot, Guilhem Guirado (captain), Rabah Slimani, Sebastien Vahaamahina, Paul Gabrillagues, Judicael Cancoriet, Kevin Gourdon, Louis Picamoles.
Replacements: Clement Maynadier, Raphael Chaume, Daniel Kotze, Paul Jedrasiak, Anthony Jelonch, Baptiste Serin, Francois Trinh-Duc, Damian Penaud.