Queensland and North Queensland Cowboys star Johnathan Thurston needs shoulder surgery and will miss the rest of the year.
Thurston, 34, was the Maroons' hero in game two of State of Origin, guiding his side to a series-levelling 18-16 win over New South Wales on Wednesday.
But that will prove to be the star playmaker's final Origin appearance, having confirmed he planned to retire from representative action after this year.
It also rules him out of the 2017 Rugby League World Cup in October-December.
"North Queensland Toyota Cowboys co-captain Johnathan Thurston will undergo surgery for an injured shoulder and will not play rugby league again in 2017," a statement from the club read.
"After consultation with club medical and football staff, his management and family, the decision was taken for Thurston to have surgery after he sustained an injury in Wednesday night's State of Origin match in Sydney.
"The timing of the surgery is still to be determined."
The injury is a huge blow to the Maroons, who clawed their way back into the series to set up a decider in Brisbane on July 12.
Thurston's absence is also a setback for the Cowboys, who sit seventh in the NRL.