Akuila Uate scored four tries in Manly Sea Eagles' 46-8 drubbing of South Sydney Rabbitohs and Johnathan Thurston was sorely missed by North Queensland Cowboys as they were beaten by Parramatta Eels.
Manly ran riot at Allianz Stadium on Friday, scoring nine tries as the Bunnies were put to the sword in their own backyard and have now lost three in a row.
Sea Eagles winger Uate was the star of the show, helping himself to four tries in a match for the first time since facing Souths during his time at Newcastle Knights six years ago.
The Fiji international was too hot for the Bunnies to handle, the lively Dylan Walker setting up all his tries as Trent Barrett's side coasted into a 30-2 lead at half-time.
Clinical flyer Uate went over twice in the space of five minutes after four-pointers from Brenton Lawrence, Curtis Sironen and Jorge Taufua. Jake Trbojevic added a sixth Manly try prior to the interval, with Walker converting for the third time in a one-sided opening 40 minutes.
Uate doubled his tally of tries on a night to remember, while Blake Green got in on the act with a ninth Manly try as they moved up to sixth in the ladder.
Clinton Gutherson racked up 16 points as resurgent Parramatta beat the injury-hit Cowboys 26-6 in Townsville.
Cowboys captain Thurston was still not fit enough to make his return from a calf injury and could miss Australia's Test against New Zealand next week.
The 2015 premiers slumped to a third defeat in four in his absence, Gutherson scoring two of four Eels tries as they claimed a third consecutive win despite losing Kenny Edwards to the sin-bin for a face slap - the first player to be ordered off for such an offence.
Will Smith scored a debut try for the Eels and there was also a rare four-pointer for captain Tim Mannah.