Yoenis Cespedes hit three of the New York Mets' seven homers in the 14-4 rout of the Philadelphia Phillies, while the Toronto Blue Jays lost again in MLB.
Lucas Duda (two), Asdrubal Cabrera and Travis d'Arnaud also went deep for the Mets, who finished with game with 20 hits, 14 of which went for extra bases on Tuesday.
It was not all good news for the Mets after starter Matt Harvey (2-0) left the game with tightness in his left hamstring after allowing two runs on five hits and striking out six in 5.2 innings.
The Blue Jays slumped to 1-6 for the season after going down 4-3 to the Milwaukee Brewers in Toronto's home opener.
Elsewhere, the Boston Red Sox eased past the Baltimore Orioles 8-1, the Washington Nationals beat the St Louis Cardinals 8-3 and the Miami Marlins saw off the Atlanta Braves 8-4.
The Cincinnati Reds accounted for the Pittsburgh Pirates 6-2, the Arizona Diamondbacks topped the San Francisco Giants 4-3, the Minnesota Twins lost 2-1 to the Detroit Tigers, the Chicago White Sox went down to the Cleveland Indians by the same scoreline after 10 innings, the Colorado Rockies were 3-2 winners against the San Diego Padres, the Texas Rangers were beaten 6-5 by the Los Angeles Angels in extras, while the Houston Astros overcame the Seattle Mariners 7-5.
MARLINS FLOURISH IN MIAMI
In Miami's first season-opener without Jose Fernandez, the club played with a string of emotion in a win over the Braves. Marcell Ozuna went deep twice and finished with six RBIs while Dee Gordon and Christian Yelich each finished with three hits as a cat enjoyed the show.
BRANTLEY INSPIRES INDIANS TO WALK-OFF WIN
Michael Brantley smacked a pitch from White Sox righty Tommy Kahnle down the left-field line, scoring Francisco Lindor from first base to give the Indians a walk-off win in their open-opener.
HAPP'S WOES CONTINUE
J.A. Happ fell to 0-2 on the season for the Blue Jays. Happ gave up four runs on nine hits in just over four innings of work while the dormant Jays offence continued to struggle. Russell Martin is still without a hit to begin the season while Troy Tulowitzki and Jose Bautista remain well below the Mendoza Line.
CARDINALS AT NATIONALS
St Louis are off to a slow start to the season and things do not get any easier against the reigning NL Cy Young Award winner Max Scherzer (1-0, 2.70 ERA) and the Nationals on Wednesday. Veteran right-handed pitcher Mike Leake (0-1, 1.13 ERA) will look to slow a potent Nationals line-up that has put up 22 runs in two straight wins over the Redbirds.