Top seed Kiki Bertens advanced to the second round of the Copa Colsanitas but defending champion Irina Falconi bowed out.
Bertens needed a little over an hour to emerge triumphant in her first-round encounter on the Colombian clay, seeing off Nina Stojanovic 6-4 6-1 on Tuesday.
Dutchwoman Bertens fired down five aces and converted seven break points at the WTA International tournament in Bogota.
Falconi's title defence ended at the first hurdle, upstaged by Dalila Jakupovic 6-2 6-4.
Slovenian Jakupovic claimed the decisive break in the second set to book her spot in the second round.
Katerina Siniakova - the second seed - eased past Jil Teichmann 6-0 6-4.
Sara Errani reached the next round after eliminating seventh seed Ekaterina Alexandrova 6-2 6-4.
Errani was broken twice as she served for the match, however the Italian was not to be denied victory.
-- WTA (@WTA) April 11, 2017
Last year's runner-up Silva Solver-Espinosa beat eighth seed Maria Sakkari 6-3 7-6 (8-6) and Francesco Schiavone knocked out sixth seed Patricia Maria Tig 6-3 6-4.
Elsewhere, fifth seed Magda Linette accounted for Nadia Podoroska 6-1 6-3, Sara Sorribes Tormo won 6-1 7-6 (7-4) against Denisa Allertova, Emiliana Arango went down 6-2 6-2 to Irina Khromacheva and Veronica Cepede Royg outlasted Beatriz Haddad Maia 2-6 6-3 6-4.