Reigning MLB champions the Chicago Cubs suffered a walk-off loss to the Milwaukee Brewers, while the Tampa Bay Rays trumped the Toronto Blue Jays.
Cubs reliever Mike Montgomery threw a wild pitch in the bottom of the 11th with the bases loaded, allowing Ryan Braun to score from third base for the 2-1 walk-off win on Friday.
Evan Longoria homered during a five-run first inning as the Rays outlasted the Blue Jays 10-8.
The Blue Jays rallied for a 7-6 lead but the Rays came back in the sixth to see off Toronto.
Elsewhere, the New York Yankees lost 6-5 to the Baltimore Orioles, the Colorado Rockies edged the Los Angeles Dodgers 2-1, the New York Mets were no match for the Miami Marlins 7-2, the Texas Rangers defeated the Oakland Athletics 10-5, the San Francisco Giants lost 7-6 to the San Diego Padres and the Washington Nationals beat the Philadelphia Phillies by the same scoreline.
The Kansas City Royals were 5-1 winners against the Houston Astros, the Cincinnati Reds shut out the St Louis Cardinals 2-0, the Detroit Tigers topped the Boston Red Sox 6-5, the Arizona Diamondbacks claimed a 7-3 victory over the Cleveland Indians, the Minnesota Twins defeated the Chicago White Sox 3-1, the Los Angeles Angels eased past the Seattle Mariners 5-1 and the Atlanta Braves went down 5-4 to the Pittsburgh Pirates.
RAYS BENEFIT FROM COLLECTIVE EFFORT
Tampa jumped on Toronto starter Francisco Liriano early, putting up five runs on the southpaw in just one-third innings of work, the shortest start of his career.
The Jays finished with 10 runs in the win thanks to two-RBI nights from Steven Souza Jr., Evan Longoria, Derek Norris, and Brad Miller.
IT"S A FIRST FOR BELT
Giants slugger Brandon Belt blasted his first career grand slam, a go-ahead shot against the Padres.
A's starter Raul Alcantara gave up eight runs on just four hits in two innings of work against the Rangers including a grand slam to Nomar Mazara, who is off to a blistering start to the season.
DODGERS BACK IN ACTION AGAINST ROCKIES
Clayton Kershaw (1-0, 1.29 ERA) held the Padres to two hits and one earned run on opening day but Saturday's start at Coors Field poses a much tougher matchup. In 32 career starts against the Rockies, Kershaw is 18-5 with a 3.08 ERA but at Coors Field, he owns a 4.63 ERA.