The Atlanta Braves and Boston Red Sox each needed 12 innings to win pitchers' duels in MLB on Wednesday.
Matt Kemp's two-run double in the 12th lifted the Braves to a 3-1 win over the New York Mets.
Red Sox catcher Sandy Leon blasted a three-run home run for a 3-0 walk-off win over the Pittsburgh Pirates at Fenway Park.
The Astros and Seattle Mariners needed a baker's dozen to decide their game, which ended on George Springer's walk-off homer as Houston completed the sweep with a 5-3 win.
The Detroit Tigers and Chicago White Sox were again rained out on Wednesday, as were the Chicago Cubs and St Louis Cardinals at Busch Stadium.
There were shut-out wins for the Los Angeles Angels (5-0 over the Oakland Athletics) and Cincinnati Reds (2-0 over the Philadelphia Phillies)
The Minnesota Twins thrashed the Kansas City Royals 9-1, the Baltimore Orioles overcame the Toronto Blue Jays 3-1, the Washington Nationals edged the Miami Marlins 6-4 and the Tampa Bay Rays beat the New York Yankees 4-1.
The Cleveland Indians edged past the Texas Rangers 9-6, the Milwaukee Brewers were too good for the Colorado Rockies 6-1, the San Francisco Giants were beaten 8-6 by the Arizona Diamondbacks and the Los Angeles Dodgers beat the San Diego Padres 3-1.
CASTRO WALKS, ESCOBAR HITS
Twins catcher Jason Castro had four plate appearances against the Royals and walked all four times. That was good for Eduardo Escobar, who hit right behind Castro and finished with two hits and four RBIs, including a three-run home run in the seventh inning.
LEON'S BIG BLAST
Leon's walk-off winner was over the Green Monster.
Rockies pitcher Tyler Chatwood gave up two of Milwaukee's three home runs in a Brewers victory. Chatwood had a solid season last year, going 12-9 with a 3.87 ERA, but his 2017 season got off to a rocky start with four runs and seven hits allowed in six innings at Miller Park.
CUBS, CARDINALS SET FOR BATTLE
After Wednesday's match was rained out, the Cubs (1-1) and Cardinals (1-1) will complete their three-game set at Busch Stadium with Jon Lester going against Lance Lynn. Lester is 12-4 all-time with a 2.04 ERA in 24 games at Busch Stadium. The Cardinals hope Lynn, who missed all of last season after undergoing Tommy John surgery, can return to form that helped him win 15 games and post a 2.74 ERA in 2014.