Billy Vunipola is set to make his international comeback from the bench when England seek to make history with a Six Nations victory over Scotland on Saturday.
The influential back-row forward returned to action for Saracens last week, having recovered from knee surgery ahead of schedule, and had been tipped to make a swift return to England's starting line-up this weekend.
However, Vunipola has been named among the replacements along with brother Mako, as Nathan Hughes retains the number eight jersey.
Victory over Scotland would put England one step away from a second successive Grand Slam triumph and ensure Eddie Jones' men equal New Zealand's record of 18 successive Test wins by a tier-one nation.
Jones has made three changes to his team - Jonathan Joseph, Jack Nowell and Ben Youngs all returning after dropping out of the starting XV for the win over Italy.
Bath centre Anthony Watson joins Billy Vunipola in being named in the matchday 23 for the first time in the tournament, following his return to fitness.
Although Dylan Hartley is again retained as captain, Joe Marler will lead England out of the tunnel at Twickenham to mark his 50th cap.
England: Mike Brown, Jack Nowell, Jonathan Joseph, Owen Farrell, Elliot Daly, George Ford, Ben Youngs; Joe Marler, Dylan Hartley (captain), Dan Cole, Joe Launchbury, Courtney Lawes, Maro Itoje, James Haskell, Nathan Hughes.
Replacements: Jamie George, Mako Vunipola, Kyle Sinckler, Tom Wood, Billy Vunipola, Danny Care, Ben Te'o, Anthony Watson.