Scotland's John Hardie will miss their final Six Nations fixtures against England and Italy after sustaining a knee injury against Wales.
The flanker was forced off in the first half of Saturday's 29-13 victory at Murrayfield and was replaced by Hamish Watson.
A scan has since revealed Hardie has suffered medial ligament damage and will play no further part in the tournament, with Scotland third in the table, four points adrift of leaders England ahead of the Calcutta Cup meeting at Twickenham on March 11.
"Scotland and Edinburgh Rugby back-row John Hardie has been ruled out of the remaining RBS 6 Nations matches with a knee injury," read a statement from Scotland Rugby.
"A MRI scan after the game confirmed the player damaged his medial collateral ligament (MCL) and is expected to be out for several weeks. He will take no further part in the championship.
"Wing Tommy Seymour sustained a blow to the ribs in the act of scoring but was fine to continue. He is not considered a concern."