England will be without Anthony Watson for the start of the Six Nations after the wing was ruled out for three to four weeks with a hamstring strain.
Watson will consequently miss the defending champions' opening match against France at Twickenham next weekend and the trip to face Wales on February 11.
Subject to his recovery, the 22-year-old could return in time for the visit of Italy on February 26.
Watson sustained the injury while at England's training camp in Portugal and underwent a scan on Saturday.
The results showed a muscular strain which will require up to one month of rehabilitation.
Watson only returned to club action with Bath last month having been sidelined since October with a broken jaw suffered at a training camp with England.
SQUAD UPDATE | Anthony Watson has sustained a muscular strain to his hamstring which will require a rehabilitation period of 3 to 4 weeks. pic.twitter.com/MHzmZF6FnJ-- England Rugby (@EnglandRugby) January 29, 2017