Grenoble bounced back from their European Challenge Cup embarrassment at Ospreys to end a run of five successive Top 14 defeats by beating Toulouse 26-22 on Thursday.
Bernard Jackman's men suffered a 71-3 demolition in Wales on Saturday but battled valiantly at home against Toulouse, with Jonathan Wisniewski leading the way by providing 16 points with the boot.
Wisniewski proved particularly invaluable for the hosts in the first half, as his three penalties and one conversion added to Loick Jammes' try.
Toulouse were then denied a first touchdown of their own by an offside infringement on the stroke of half-time, allowing Grenoble to take a 16-9 lead into the break.
Xavier Mignot scored Grenoble's second try 12 minutes into the second half, though Edward Sawailau's yellow card offered encouragement to Toulouse, who pulled themselves back into contention through a penalty try and Jean-Marc Doussain's conversion.
Both Wisniewski and Doussain added further penalties, but Grenoble's stubborn defence did just enough to secure a much-needed victory, lifting them off the foot of the table and above Bayonne.