Cricket South Africa (CSA) has accepted the decision to uphold Faf du Plessis' ball tampering charge.
Michael Beloff QC, the ICC's independent commissioner, dismissed the Proteas captain's appeal after he was deemed to have breached the governing body's code of conduct.
Du Plessis was found guilty after allegedly applying saliva from a sweet or mint to the ball during the second Test against Australia at Hobart last month.
The 32-year-old was fined his entire match fee, although he was not suspended from playing in the third Test at Adelaide, in which he went on to make a defiant century.
Du Plessis said he felt he had been made a scapegoat, but the batsman was unable to overturn the ICC's decision.
CSA chief executive Haroon Lorgat responded to the verdict by saying: "We are satisfied with the matter being given due consideration by a person independent of the ICC.
"Both CSA and Faf believed that this appeal was imperative considering the important principles at stake.
"In our view, the fact that Mr Beloff deliberated for some time after hearing complex legal arguments from both sides demonstrates that this matter does indeed require further consideration and clarification from the ICC and the MCC.
"Notwithstanding the outcome of the appeal and Mr Beloff's helpful rulings on the matter, we hope that further reviews of the Code of Conduct and the laws of the game takes place as players will no doubt continue to seek clarification as to what is or is not permissible in the light of this case."