Alastair Cook has confirmed James Anderson will miss England's final Test in India due to soreness.
The seamer was absent from the tour to Bangladesh in October due to a shoulder injury, which also caused him to miss the opening Test of the series with India.
Anderson returned for the past three outings, all of which England lost, leaving them with little more than pride to play for in the final meeting in Chennai, which starts on Friday.
But the tourists will have to make do without their all-time leading Test wicket taker, after captain Cook announced in his media conference on Thursday that Anderson would miss out.
"He's just sore from the game [fourth Test] and it's not worth the risk with his past," Cook said.
"We're very confident Jimmy can make a big contribution over the next couple of years. It's not just about getting him through."
A decision is yet to be made on the fitness of Stuart Broad, who has missed the previous two Tests with a foot injury.