After a busy midweek full of European football fun, it's back to Premier League action for England's top clubs.
We've picked out five of the most intriguing talking points for you to mull over, and we start with a trip to Old Trafford.
Another record for Rooney?
On Thursday, Wayne Rooney became Manchester United's outright, all-time highest scorer in Europe after his strike in the 4-0 win over Feyenoord moved him beyond Ruud van Nistelrooy to 39 continental goals for the club.
The effort also took him to 248 goals for United in total, meaning he is now just one behind their overall top scorer Sir Bobby Charlton, whose tally he will hope to draw level with, or even surpass, when the Red Devils play West Ham at Old Trafford on Sunday.
Also on Sunday, Everton boss Ronald Koeman will be back at St Mary's to face Southampton for the first time since he left to take charge of the Toffees in the summer.
It will certainly be interesting to see what kind of reception the Dutchman gets from the home crowd, after he enjoyed considerable success over two seasons with the south-coast club before making the switch.
Will Chelsea's run continue?
Chelsea are the current Premier League leaders and have demonstrated fantastic form, with their last six league games showing six wins, 17 goals scored and none conceded.
On Saturday evening they host a fifth-placed Tottenham side who are aiming to bounce back from Champions League disappointment earlier this week, and whose striker Harry Kane is among the goals once more.
It looks a testing assignment for Chelsea - although the fact Antonio Conte's men swept aside Manchester United 4-0 and then Everton 5-0 in their previous two home matches seems ominous for Spurs.
Is Yaya Toure really back?
Yaya Toure grabbed the headlines last weekend as he returned from his exile at Manchester City under Pep Guardiola with a bang, marking his first Premier League appearance of the season by netting twice in his side's 2-1 win at Crystal Palace.
With the problems between the midfielder and his boss Guardiola apparently resolved and Toure seemingly back in the groove, it is now a question of whether the 33-year-old builds on his impressive comeback at Burnley in Saturday's lunchtime kick-off.
Pressure on at the Liberty Stadium
Swansea host Crystal Palace later on Saturday and both clubs' managers are in serious need of a win.
The rock-bottom Swans are yet to record a victory following Bob Bradley's appointment as their boss in early October, while Alan Pardew's Palace, who are 16th, have lost each of their last five games.
Will Palace perish, or will Swansea stumble?