Wales scrum-half Rhys Webb could miss the Six Nations due to the injury he suffered against Australia last weekend.
Webb suffered ankle ligament damage as his side were trounced 32-8 by the Wallabies and will undergo surgery on Friday.
The Welsh Rugby Union (WRU) confirmed the 27-year-old faces at least 12 weeks of rehabilitation, jeopardising his participation in the Six Nations, which begins on February 4.
"Scrum-half Rhys Webb has been released from the Wales squad due to an ankle injury," read a WRU statement.
"Webb suffered ankle ligament damage in the fixture against Australia and will undergo surgery tomorrow [Friday].
"It is expected that Webb will undertake a period of rehabilitation of at least 12 weeks."
Prior to the WRU's statement, Webb had taken to Twitter to express his frustration at being forced to go under the knife.
Webb posted a mocked-up image that showed his head superimposed on the body of Mario Balotelli as the former Manchester City striker displayed his famous 'Why Always Me?' t-shirt.
Accompanying the picture was a message that read: "Thanks everyone for the messages .Yep ANOTHER operation on the cards tomorrow! Time to get this ankle sorted. See you in the NY."
Thanks everyone for the messages .Yep ANOTHER operation on the cards tomorrow! Time to get this ankle sorted. See you in the NY pic.twitter.com/qoATo6opMO-- Rhys Webb (@Rhys_W009) November 10, 2016