Mike Williams has become the latest player to be ruled out of England's autumn internationals after the Leicester Tigers flanker broke his arm for a third time.
England head coach Eddie Jones has already lost a host of players ahead of the clashes with South Africa, Fiji and Argentina next month, as well as a Test against Australia on December 3.
Williams will play no part in those encounters at Twickenham, as he faces up to 12 weeks on the sidelines as a result of an injury sustained in a tackle drill with club team-mate Matt Toomua ahead of the victory over Worcester Warriors on Saturday.
Tigers director of rugby Richard Cockerill said: "Mike felt he had done something but thought it was just a bang, but the medical guys looked at it and Mike was pulled out before the kick off.
"He is in a cast and will take some specialist advice. But it looks like eight to 12 weeks out - not four to six because of the history of the injury."
He added: "Mike is bitterly disappointed. You would have thought that had he continued the way he has been doing for the last couple of weeks he would have had a chance to play for England."