Andile Phehlukwayo has been called up to the South Africa one-day international squad to face Australia and the uncapped all-rounder could make his debut against Ireland along with Temba Bavuma and Dwaine Pretorius.
Phehlukwayo has been rewarded for some encouraging performances for South Africa A and the 20-year-old is in line to make his international bow against Ireland in Benoni on September 25.
Test batsman Temba Bavuma is also poised to make first appearances for the Proteas against the Irish, but has not been selected for a five-match series against world champions Australia - which starts on September 30.
The same goes for all-rounder Dwaine Pretorius, who is set to get his first chance in the 50-over format versus Ireland at Willowmoore Park.
Injured paceman Morne Morkel and batsman Rilee Rossouw will play no part, but Dale Steyn and David Miller have been named in the squads.
"Morne Morkel and Rilee Rossouw were not considered for selection as they continue to recover from injury and a lack of match fitness respectively, while AB de Villiers is on track to return from the injury that kept him out of the Sunfoil Test Series against New Zealand," Cricket South Africa selection committee convener Linda Zondi said.
"Andile was our leading wicket-taker for South Africa A in the recently concluded quadrangular series in Australia and he has been knocking on the door for some time following his strong performances in last season's Momentum One-Day Cup.
"Both he and Dwaine have shown excellent form recently and the same applies to David Miller, who topped the batting averages in Australia for the South Africa A squad with the outstanding figures of 332 runs at an average of 110 with a strike rate of 93.
"It remains our practice to reward players who do well at franchise and South Africa A level.
"As far as Temba Bavuma is concerned we want to see what he can do in the ODI format after the extremely successful run he has had in the Test squad where he has averaged 66 during the current calendar year.
"Rilee Rossouw played two practices matches for the VKB Knights at the weekend when he batted freely but still had issues with his throwing and it will be beneficial for him to start his comeback in the Sunfoil Series four-day competition which starts early next month."
South Africa squad to play Ireland: AB de Villiers, Temba Bavuma, Farhaan Behardien, Quinton de Kock, JP Duminy, Faf du Plessis, David Miller, Chris Morris, Wayne Parnell, Aaron Phangiso, Andile Phehlukwayo, Dwaine Pretorius, Kagiso Rabada.
South Africa squad to play Australia: AB de Villiers, Kyle Abbott, Hashim Amla, Farhaan Behardien, Quinton de Kock, JP Duminy, Faf du Plessis, Imran Tahir, David Miller, Chris Morris, Wayne Parnell, Aaron Phangiso, Andile Phehlukwayo, Kagiso Rabada, Tabraiz Shamsi, Dale Steyn