Alistair and Jonny Brownlee achieved a British sporting first by winning gold and silver in the triathlon.
They were the first British brothers to finish one and two in an individual event at a summer Games and the first from any country since 1960.
Here we looks at how other siblings have fared in Rio...
Andy and Jamie Murray
Arguably the most famous siblings in British sport had hoped to win a medal together in doubles but were beaten in the first round. Andy picked himself up from the bitter disappointment to win a second successive singles gold.
Serena and Venus Williams
Not a vintage Games for the veteran American sisters, who are the most successful Olympic tennis players in history. Venus added a silver medal in mixed doubles with Rajeev Ram to her four golds but Serena left empty-handed.
Paul and Gary O'Donovan
The O'Donovan brothers made history themselves by winning Ireland's first rowing medal in the lightweight double sculls. They subsequently gave a hilarious interview to RTE to cement their hero status.
Cindy Ofili and Tiffany Porter
British sisters Cindy Ofili and Tiffany Porter both compete in the 100m hurdles and both missed out on medals in Rio. Ofili looked set to take the bronze but was pipped to the race line by the US Kristi Castlin, while Porter came in seventh.
Cate and Bronte Campbell
Like the Brownlees, the Australian swimming sisters compete against each other. They both reached the final of the 50 metres and 100m freestyle, although neither was able to win a medal. They did team up to take gold in the relay, however.
Michael and John Whitaker
The veteran British brothers have now competed in show jumping at a combined 11 Olympics. They won gold together in the team competition in Los Angeles in 1984 but there will be no medals from Rio.
Becky and Ellie Downie
A first Olympics for 17-year-old gymnast Ellie and a second for 24-year-old Becky. They joined forces to help Britain to fifth place in the team competition while Ellie finished 13th in the all-around.
Leila, Liina, and Lily Luik/Lisa and Anna Hahner/Kim Hye-song and Kim Hye-gyong
The women's marathon was the place to go for siblings. Estonian sisters Leila, Liina, and Lily made history as the first Olympic triplets to compete together. Twins Lisa and Anna, meanwhile, were criticised in their home country of Germany for crossing the line holding hands. The Kim twins from North Korea also finished together in 10th and 11th places.
Sonny Bill and Niall Williams
Brother and sister Sonny Bill and Niall Williams were picked for their respective New Zealand teams in rugby sevens. Global star Sonny Bill's Games came to an early end because of an Achilles injury but Niall took home a silver medal.