The Williams sisters will aim to make even more Wimbledon history on Thursday as they play in the ladies' semi-finals at the All England Club.
It is the 11th time that Serena and Venus Williams have both reached the last four of the same Grand Slam.
If they both win it will be fifth time they will have played each other in the Wimbledon final, the last time being in 2009.
Venus, who at 36 is the oldest player in a Grand Slam semi-final since Martina Navratilova graced Wimbledon at 37 in 1994, plays Angelique Kerber while her younger sister takes on Elena Vesnina of Russia.
Thursday will also see the inaugural ladies' and gentlemen's wheelchair singles at the All England Club.
Wimbledon is the last of the four Grand Slams to have a wheelchair singles competition, and the prize money for the wheelchair events is £200,000.
Among those in the draw are Britons Gordon Reid and Jordanne Whiley, who said they hope their achievements will inspire younger generations of wheelchair users.
Reid, a keen footballer and tennis player as a child before he took up the wheelchair sport after contracting transverse myelitis shortly before his 13th birthday, said: "If any kids or young people with disabilities get the opportunity to see us playing sport at a high level then they can be inspired to do a similar thing, and know there's a lot in life you can achieve when you're in a chair."
Whiley, who in 2014 won a calendar year Grand Slam of all four tournaments in the doubles, said: "Sport completely changed my life from when I was a young girl.
"I was very insecure, didn't have many friends. I was born with disability and was in and out of hospital constantly.
"When I got into tennis I became confident, like I really believed in something, which made me believe in myself. I know it can really change your life.
"For me it's really important that young people do see that, especially for young disabled people - that there's something more out there.
"It's not just you in a wheelchair and your life has ended. Your life actually can just begin from that."