New South Wales half-back Adam Reynolds will miss State of Origin III because of a shoulder injury.
The South Sydney Rabbitohs playmaker missed training on Wednesday, due to the injury suffered in the second game of the series on June 22.
Reynolds was ruled out by the Blues later in the day, with his replacement not yet named.
The Blues host the final game of the series next Wednesday, but they have already lost the series.
With their 6-4 and 26-16 wins, the Maroons sealed a 10th series in 11 years.