The Toronto Blue Jays handed the Boston Red Sox a second-straight loss as their series kicked off with a 5-2 win for the visitors.
The Blue Jays are now just two wins off matching the Red Sox record after getting off to a flyer from a two-run Edwin Encarnacion homer at the top of the first, before Devon Travis matched that effort at the top of the eighth.
The Los Angeles Angels notched 15 hits as they trounced the Pittsburgh Pirates 9-2, with Kole Calhoun's fourth-inning homer a highlight.
Elsewhere, the Chicago Cubs shut-out the Arizona Diamondbacks 6-0, the Philadelphia Phillies were 6-3 winners of the Milwaukee Brewers and the Baltimore Orioles won a tight won against the New York Yankees 6-5.
The Detroit Tigers defeated the Chicago White Sox 10-3 in an emphatic display in which they scored seven of their 10 runs in their last three innings.
The Kansas City Royals went down again to the Cleveland Indians, losing 6-1, while the New York Mets ran out 6-2 winners over the Miami Marlins.
The Texas Rangers had Adrian Beltre's five-RBI showing to thank for their 7-3 win over the Seattle Mariners, while the Houston Astros' seven-run first inning set them on their way to a 12-2 drubbing of the Oakland Athletics.
Meanwhile, the Minnesota Twins lost 4-2 to the Tampa Bay Rays, the San Francisco Giants won 5-1 against the St. Louis Cardinals, the Los Angeles Dodgers defeated the Atlanta Braves 4-2, the San Diego Padres shut-out the Colorado Rockies 4-0 and the Cincinnati Reds were 7-2 winners over the Washington Nationals.
GATTIS GETS RUNS
The Houston catcher was on fire at the plate, going four-for-five with a home run and four RBIs in the Astros' 12-2 rout of the Athletics.
Adrian Beltre blasted a three-run homer in the first inning to give the Rangers a 3-0 lead over the Mariners. He also hit a two-run double in the third to cushion the Rangers' 7-3 win.
The Dodgers placed Yasiel Puig on the 15-day disabled list on Friday after he strained his left hamstring. Scott Van Slyke was called up from the DL to take his place when the Braves visited Dodger Stadium.
Meanwhile, David Ortiz became the third Red Sox player after Ted Williams and Carl Yastrzemski to hit 500 doubles and 400 home runs. He hit his 500th double in Boston's 5-2 loss to the Blue Jays.
HAMMEL OUT FOR REDEMPTION
Jason Hammel saw his last start cut short with a hamstring cramp, but will try to redeem himself in the second game of the Cubs' series against the Diamondbacks. Hammel will face off against Edwin Escobar, who had a terrible MLB debut against the Astros on Monday. Escobar allowed eight runs in 3 1/2 innings before he was pulled.