Jordan Spieth surged into the Dean & DeLuca Invitational lead thanks to a five-under 65 in the third round on Saturday.
The American world number two's only blemish came at the 18th as he moved into 12 under overall at the Colonial Country Club.
Spieth will carry a one-shot lead over Ryan Palmer (66) and Webb Simpson (67) into the final round.
The two-time major champion had three birdies on the front nine before further gains at the 11th, 12th and 16th holes.
However, Spieth found the rough off the tee at the last and finished with a bogey at the par-four hole.
The 22-year-old gets another chance to return to winning ways, having collapsed at the Masters and AT&T Byron Nelson.
Palmer was left to rue back-to-back bogeys at four and five, while Simpson endured an up-and-down round.
Harris English (64), Kyle Reifers (67) and Martin Piller (68) are tied for fourth at 10 under, a shot ahead of Jason Dufner (66) and two clear of Chris Stroud (64).
Overnight leader Bryce Molder slipped to a tie for ninth at seven under, having completed his second and third rounds on Saturday.
Molder finished with a 69 in the second before an even-par 70 in the third left him five shots off the lead.
Alongside Molder are Patrick Reed (69), Anirban Lahiri (68) and Matt Kuchar (63), the latter surging into contention.
Defending champion Chris Kirk made the cut and carded a five-under 65 in the third round to sit tied for 15th.
The 2014 champion, Adam Scott, also reached the weekend, but he sits at two over and out of contention.