Most attention on the final day of the Premier League season will focus on Manchester as the city's two heavy hitters go in search of the final Champions League place on offer.
Just four years ago City and United were the chief protagonists in the most epic final day in Premier League history and while this time round the prize might not be as great, it is significant.
City travel to Swansea knowing that a point will almost certainly be enough to make sure that Pep Guardiola takes over a Champions League outfit.
United host Bournemouth knowing they must win to have any hope of leapfrogging their city rivals and give boss Louis van Gaal ammunition to fire back at those who have suggested his Old Trafford career hangs in the balance.
There is also, however, a situation where United could fail to qualify for Europe at all through their league position.
Van Gaal's men would drop down to seventh if they lose and West Ham and Southampton - who both have better goal difference - secure a draw and a win respectively.
United could of course still book a Europa League place by beating Crystal Palace in the FA Cup final, but the pressure of the occasion would be ramped up another level if that was the case.
The top eight could all be in Europe next season - if Liverpool win the Europa League and United the FA Cup - which would confirm that Southampton and West Ham qualify no matter what they do this weekend.
It would be extremely risky business for them to assume they are qualified already, though.
If United lose the FA Cup final to Palace, the London club would get a Europa league place - leaving just two spots for the clubs at the top end of the table.
With the title race and relegation battles complete there is little else to play for on the final weekend, although Chelsea's miserable title defence could yet end in 10th place.
If the Blues lose to champions Leicester, Stoke will overhaul them with a home win over West Ham, while managerless Everton could drop from 12th to 16th as they begin life after Roberto Martinez.