John Terry may have played his final game for Chelsea following his red card in the 3-2 defeat to Sunderland, and Guus Hiddink rued referee Mike Jones' decision.
After being booked for a foul on Defoe, Terry was shown a second yellow card in the fifth minute of second-half stoppage time when he collided late with Wahbi Khazri.
Having already seen red in the 3-0 win over West Brom last August, the FA confirmed to Omnisport the Chelsea captain will subsequently serve a two-match ban, ruling him out for the remainder of the campaign.
With no resolution over Terry's contract, which is due to expire at the end of the season, the defender - who has been at the club since 1995 - may not appear again, and Hiddink was disappointed with the dismissal.
"John Terry was a double yellow, I think it was a little bit over the top, the decision," he told BBC Sport.
Terry made his Chelsea debut in 1998 and captained the side for the first time as a 20-year-old before going on to make over 700 competitive appearances for the club.
The centre-back has been the figurehead of the most successful period in Chelsea's history, claiming four Premier League titles, five FA Cups and the Champions League in 2011-12.