Chris Sale improved to 6-0 this season as the Chicago White Sox claimed a win, while Clayton Kershaw led the Los Angeles Dodgers.
Sale struck out six over 5.1 innings as the White Sox overcame the Baltimore Orioles 7-1.
The Dodgers needed Kershaw and he delivered, allowing just three hits and striking out 14 in a complete-game shutout and 1-0 win over the San Diego Padres.
Joining the Dodgers in ending a six-game slide were the Cincinnati Reds, who needed 11 innings to get past the Pittsburgh Pirates 6-5.
The New York Mets had their eight-game winning streak ended, suffering a 6-1 loss to the San Francisco Giants.
Marcus Stroman led the way on his 25th birthday, pitching the Toronto Blue Jays past the Tampa Bay Rays 5-1, while the Detroit Tigers overcame the Minnesota Twins 6-5.
The Milwaukee Brewers thrashed the Miami Marlins 14-5, the Los Angeles Angels beat the Texas Rangers 9-6 and the Colorado Rockies were 6-3 winners against the Arizona Diamondbacks.
The Kansas City Royals ended their five-game losing streak by beating the Seattle Mariners 4-1, the Atlanta Braves had a 4-3, 10-inning win over the Chicago Cubs and the Boston Red Sox swept the New York Yankees with an 8-7 win.
The Philadelphia Phillies edged past the Cleveland Indians 2-1, the Washington Nationals beat the St Louis Cardinals 6-1 and the Houston Astros were 2-1 winners over the Oakland Athletics.
KERSHAW DOMINATES PADRES
Dodgers ace Kershaw put on a show against the Padres by tossing a complete-game shutout with 14 strikeouts. He also became the first Dodgers pitcher to win a 1-0 game in which he drove in the only run since Fernando Valenzuela in 1984. Kershaw is now 3-1 with a 1.96 ERA this season.POLANCO GOES DEEP
Pirates outfielder Gregory Polanco smacks one out of the park.
The Nationals secured their first series sweep of three or more games at St Louis since 1988, but superstar Bryce Harper had a rough day, striking out in all four of his at-bats.
CUBS TAKE ON PIRATES
Chicago send out Jason Hammel (3-0, 0.75 ERA), who like last year is off to a great start to the season, against the Pirates on Monday. Pittsburgh ace Gerrit Cole (2-2, 2.78) will try to hand him his first loss as two of the best National League (NL) teams square off.
Washington's rotation has been incredible so far this season and Monday's starter, Gio Gonzalez (1-1, 1.42) has been a big part of that. Edinson Volquez (3-1, 3.34 ERA) will try to keep pace with the White Sox in the competitive American League (AL) Central.