Argentina will face off against Italy in an international Test on June 11, after the two rugby associations announced the match on Thursday.
Italy will travel to Santa Fe to face the Pumas in Argentina for the match as the two sides resume their rugby rivalry.
Argentina are on a winning streak of five games against Italy, the longest streak in the history of Tests between the teams.
Historically, Argentina have been the dominant side too, winning 14 of 20 Tests contested, with Italy winning four and the other Test being drawn.
Italy put up a good fight last time out, when Argentina prevailed 20-18 in Genoa back in November 2014.
Union Argentina de Rugby (UAR) president Carlos Araujo said he was excited to take the national team back to Santa Fe and expected a tough challenge from Italy.
"Santa Fe is one of the cities that have always been pleasant with Los Pumas," he said.
"It's always very friendly. For Argentina Union to come to this venue is very interesting. The times we played here we have always been alright."