David Wright and Noah Syndergaard led the New York Mets to a 5-2 win over the Philadelphia Phillies, while Trevor Story hit another homer on Monday.
Wright homered twice - his first homers of the year - and Syndergaard struck out eight over seven innings.
Story blasted a solo homer in the eighth inning to set an MLB record as the Rockies beat the Cincinnati Reds 5-1.
The Toronto Blue Jays split their four-game series with the Boston Red Sox courtesy of a 4-3 win.
The Miami Marlins got past the Washington Nationals 6-1, the Chicago Cubs shut out the St Louis Cardinals 5-0 and the Los Angeles Angels blanked the Chicago White Sox 7-0.
The Minnesota Twins edged the Milwaukee Brewers 7-4, with rain bringing the clash to an end after six innings, while the Arizona Diamondbacks rallied past the San Francisco Giants 9-7 through 11 innings.
WRIGHT BLASTS TWO HOMERS
Veteran third baseman Wright connected on a pair of solo home runs in the Mets' win over the Phillies. It was his first multi-homer game since June 20, 2013 and gave him 22 career long balls at Citizens Bank Park, the most by any opposing player in the stadium's history.
STORY KEEPS HITTING
Rockies shortstop Story set an MLB record for fewest games to eight career home runs with a 423-foot bomb against the Reds.
Same old Story. https://t.co/4q8tbbg4Tu pic.twitter.com/7XrczY5Fr8-- MLB (@MLB) April 19, 2016
SANTIAGO LEADS ANGELS
Angels left-hander Hector Santiago tied a career-high with 10 strikeouts against the White Sox. Chicago were fooled all night, swinging and missing 20 times while failing to put a run on the board against Santiago, who allowed just two hits over seven innings.
ASTROS MEET RANGERS, NATIONALS VISIT MARLINS
The battle for Texas begins with Scott Feldman (0-1, 3.48 ERA) taking the hill for the Astros against Derek Holland (1-0, 2.31 ERA) and the Rangers, who won 13 of 19 against the Astros last season.
Stephen Strasburg (2-0, 1.98 ERA) will toe the rubber against a pesky Marlins line-up he has struggled against in his career. Strasburg is just 10-7 with a 3.69 ERA against the Marlins, who combined for a .309 average against the right-hander last season. The Marlins will counter with southpaw Adam Conley (0-0, 3.86 ERA).