The Baltimore Orioles stayed perfect courtesy of a 9-5 win over the Boston Red Sox, despite falling behind 2-0 in the first inning.
J. J. Hardy hit a pair of two-run homers, while Mark Trumbo scored three runs to maintain the Orioles' super start to the season.
The New York Yankees opened their series against the Toronto Blue Jays with a 3-2 win courtesy of Jacoby Ellsbury's RBI single in the seventh, while the San Diego Padres were shut out by the Philadelphia Phillies in a 3-0 loss.
Bryce Harper's two-out, two-run double in the eighth inning proved the difference in the Washington Nationals' 2-1 win over the Atlanta Braves, the Arizona Diamondbacks spoiled the Los Angeles Dodgers first home game of the season in a 4-2 win and the Detroit Tigers accounted for the Pittsburgh Pirates 8-2.
Jeff Samardzija became the first pitcher to contain Colorado Rockies rookie Trevor Story, striking him out three times in the San Francisco Giants' 7-2 win, as Lorenzo Cain's three-run homer in the first inning was enough to lead the Kansas City Royals to a 3-2 win over the Houston Astros.
Elsewhere, the Miami Marlins triumphed over the New York Mets 2-1, the Tampa Bay Rays beat the Cleveland Indians 5-1, the Texas Rangers beat the Seattle Mariners in an 8-0 shutout and the Oakland Athletics went down to the Los Angeles Angels 5-4.
Orioles outfielder Trumbo continued his hot streak. Trumbo went three-for-four with a home run, two RBIs and three runs scored as he helped Baltimore become just the 28th team since 1903 to start a season 7-0 or better.
GOLDSCHMIDT CONTINUES DODGERS DOMINANCE
Paul Goldschmidt loves playing the Dodgers and he delivered again as his tie-breaking homer set up the Diamondbacks' win.
"It's a tie game, I'm just trying to find a way to get on base," Goldschmidt said of his homer. "Fortunately I was able to get it out of there. It was a good job for us to be able to tack on a few more, and the bullpen did a great job."
BRAVES HORROR START CONTINUES
This is just the third time the Braves have started a season 0-7 since moving to Atlanta in 1966, and their first since 1988.
Meanwhile, Hardy's two homers were the shortest of the season, the first a 327-foot effort before smashing a 339-footer in the seventh.
BLUE JAYS SEEK IMPROVEMENT
It is too early in the season for a game to be important, but Toronto have lost five of their last six - all against American League (AL) East opponents. J.A. Happ (0-0, 3.00 ERA) will try to right the ship against Michael Pineda (1-0, 10.80 ERA).