The Florida Panthers clinched the NHL Atlantic Division title following their 4-1 win over the Montreal Canadiens on Tuesday.
It took just 10 seconds for the Panthers to take the lead courtesy of Aleksander Barkov, but Alex Galchenyuk tied things up midway through the second period.
The game appeared to be headed into the final period at 1-1 but Nick Bjugstad scored with 13 seconds left to restore the Panthers' lead.
From there they were hardly troubled, goals to Greg McKegg and Jiri Hudler sealing the win and the title for the Panthers.
The New York Islanders sealed their spot in the play-offs thanks to a 4-3 overtime win against the Washington Capitals.
Christopher Gibson, the number four goaltender at the Islanders, got the call after injuries to the main goalies and made 29 saves for his first ever NHL win.
The victory was even more impressive considering the Islanders were 3-1 down in the final period, with Thomas Hickey scoring the winner two minutes, 13 seconds into OT after an impressive fightback.
Joining them in the post-season are the Minnesota Wild despite going down 3-0 to the San Jose Sharks.
The Wild benefitted from the Colorado Avalanche's 4-3 loss to the Nashville Predators to make the play-offs.
The Tampa Bay Lightning also qualified for the post-season despite suffering defeat, with the New York Rangers prevailing 3-2.
Jaccob Slavin scored his first goal in 52 games to help the Carolina Hurricanes defeat Boston 2-1, meaning the Bruins are tied for a wildcard spot.
The Pittsburgh Penguins won their seventh straight game with a 5-3 victory over the Ottawa Senators, while the Winnipeg Jets beat the Anaheim Ducks 2-1 in OT.
In other results, the Los Angeles Kings edged the Calgary Flames 5-4 in OT, the Chicago Blackhawks upstaged the Arizona Coyotes 6-2, and the New Jersey Devils went down to the Buffalo Sabres 3-1.