Danny Welbeck urged Arsenal to learn from their Champions League exit as Barcelona forward trio Neymar, Luis Suarez and Lionel Messi gave Arsene Wenger's men a lesson in clinical finishing.
Neymar opened the scoring on Wednesday, building on a 2-0 aggregate lead established during the first leg by Messi.
Mohamed Elneny netted his first Arsenal goal to equalise six minutes into the second period but an acrobatic Suarez volley and a trademark dinked finish from Messi made it 3-1 on the night for Luis Enrique's team, who were often short of their sublime best in chalking up a 38th game unbeaten in all competitions.
Welbeck was among the culprits as Arsenal passed up a number of presentable chances in either half and the England forward struggled to look towards plenty of positives for the visitors that were undermined by a lack of cutting edge
"We had a plan to try and get through to the next round," he told BT Sport after Arsenal departed in the round of 16 for a sixth consecutive season.
"It's a difficult occasion for us but unfortunately we couldn't get through.
"We had a couple of opportunities where we should have done better with it and with their quality that they've got they're very clinical. There's a lot to be learned.
"[Camp Nou] is a place where you want to leave your mark and there were certain occasions where we could have done things better. It's disappointing."