Premier League rivals Manchester United and Liverpool have been drawn to face each other in the Europa League last 16.
The open draw allowed for teams from the same nation to be paired together and sees United and Liverpool pitted against one another for the first time in European competition.
United came from behind to progress past Midtjylland in the last round, while Liverpool saw off Augsburg 1-0 on aggregate.
Tournament favourites Borussia Dortmund have been dealt a tricky tie against another Engligh club in the form of Tottenham, while defending champions Sevilla face off against final hosts Basel.
Gary Neville avoided being drawn against his former club and is tasked with preparing his Valencia side for a two-legged clash with Athletic Bilbao, and Villarreal meet Bayer Leverkusen in another mouthwatering tie.
Elsewhere, Shakhtar Donetsk face Anderlecht, Sparta Prague meet Lazio, and Fenerbahce have been drawn against Braga.