There were few surprises on an action-packed day of the Rio Open as no less than 14 games took place on Tuesday following Monday's wet weather.
Hot and humid conditions made life tough for the players but second seed David Ferrer still managed a strong performance to see off Chilean wildcard Nicolas Jarry 6-3 7-6 (7-3).
There were plenty of break-point opportunities for both players as Ferrer converted four of his 10 while saving six of the nine he faced.
Austrian fifth seed Dominic Thiem showed no signs of slowing down after taking out the Argentina Open earlier in the week, cruising through his first-round match with a 6-3 6-4 victory against Pablo Andujar.
Top seed Rafael Nadal beat Pablo Carreno Busta 6-1 6-4 in a routine start to his title defence, which was delayed at the end of the first set by rain.
The 14-time grand slam champion won 63 per cent of points on Carreno Busta's second serve.
Jack Sock - the sixth seed - was a shock exit as he fell to world number 46 Federico Delbonis 7-5 6-1.
Brazilian eighth seed Thomaz Bellucci joined Sock in exiting as he came unstuck against Ukrainian Alexandr Dolgopolov, losing 6-7 (3-7) 7-5 6-2 in a hard-fought contest, while fellow Brazilian Joao Souza lost to Diego Schwartzman 6-3 6-2.
Italy's seventh seed Fabio Fognini came through his match against Aljaz Bedene 7-5 6-3, Nicolas Almagro prevailed against fellow Spaniard Daniel Munoz De La Nava 6-1 3-6 6-4.
Inigo Cervantes joined Almagro in the second round after trumping Taro Daniel 3-6 7-5 6-2.
Daniel Gimeno-Traver and Albert Ramos-Vinolas made it at least five Spaniards in the second round with wins over Juan Monaco (5-2) and Dusan Lajovic (3-4), who both retired respectively.
Pablo Cuevas saw off Facundo Bagnis 6-2 6-0, Santiago Giraldo saw off Gastao Elias 6-4 7-6 (7-5) and Paolo Lorenzi defeated Marco Cecchinato 6-4 3-6 6-1.
Jo-Wilfried Tsonga's first-round clash against Thiago Monteiro was postponed due to rain.