Argentina Rugby Union (UAR) president Carlos Araujo has confirmed the Pumas could stage their home Rugby Championship match against Australia at Twickenham.
Discussions have taken place between the two unions ahead of this year's competition - due to begin on August 20 - with Araujo keen to capitalise on Argentina's growing popularity in world rugby.
Their home match on the final weekend of the championship has been identified for potential relocation, taking the competition to the Northern Hemisphere for the first time.
"Taking a home fixture to Twickenham and London is very important for the UAR and for Argentine rugby," Araujo is quoted as saying by the UAR's official website.
"The fact our team could play a home fixture at such an extraordinary stadium says everything about the standing of our side in the rugby world.
"The Rugby Championship is without doubt one of the most important competitions in the world and to take one of the games to the Northern Hemisphere would allow us to be the home side in the country where our sport was born."
Argentina played Australia at Twickenham in the Rugby World Cup semi-finals, losing 15-29, and beat the Barbarians 49-31 there in November.