Dale Steyn has been ruled out of the fourth and final Test between South Africa and England.
The seamer missed the second and third Tests after failing to recover from a shoulder injury sustained in the 241-run defeat in the first Test in Durban.
And Steyn will not be available for the finale - which starts on Friday - as South Africa bid to finish a series on a high in Centurion after England moved into an unassailable 2-0 lead with a seven-wicket win in the third Test at Wanderers.
A Cricket South Africa statement read: "Dale Steyn has not recovered from a shoulder injury and will not be available for selection for the last Test, and all efforts will be made to have him ready for the one-day international series starting at the end of the month."
Meanwhile, wicketkeeper Quinton de Kock faces a fitness test to determine if he can play at Supersport Park. De Kock missed out on the third Test because of a knee injury suffered while walking his dogs.
Stiaan van Zyl - who has scored just 69 runs in five innings so far at the top of the Proteas order - has been released from the squad.
Despite the disappointment of following up a Test series defeat in India with a home loss to England, fast bowler Kagiso Rabada is remaining upbeat.
"There are always going to be up and downs in cricket and in life," Rabada said. "The good times will come and we will look back at the tough times and think 'look where we were and look where we are now'.
"It happens to everyone, unfortunately it is happening to us right now but we have to stick together as a team and stay positive.
"There is another game to play, we have to look to the future. We are trying to stay positive, there is another match starting on Friday and we are going to rock up and play hard.
"We are not going to throw in the towel, it's unlike us to do that."