The Eagles are on a run of just two wins in 14 matches, heaping the pressure on Roy Hodgson as speculation continues over his future at the club.
Injuries to Michael Olise, Eberechi Eze and Marc Guehi have significantly weakened Palace too, lowering the mood further after a hapless 4-1 defeat by rivals Brighton last time out.
Chelsea have not exactly been convincing themselves for much of the season, but Mauricio Pochettino will hope an impressive display at Villa Park in the FA Cup can help at last kick the campaign into gear.
How to watch Crystal Palace vs Chelsea
TV channel: In the UK, the game will be televised live on Sky Sports Premier League and Main Event, with coverage of Monday Night Football beginning at 6:30pm GMT ahead of an 8pm kick-off.
Live stream: Subscribers can also catch the contest live online via the Sky Go app.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog, with expert analysis from Nizaar Kinsella at Selhurst Park.