Jacob Rees-Mogg is self-isolating as one of his children awaits a Covid-19 test result.
The Commons Leader was absent from the weekly business questions session, in which he updates MPs about the debates scheduled for the following week.
Deputy chief whip Stuart Andrew stood in for Mr Rees-Mogg on Thursday.
Father-of-six Mr Rees-Mogg wrote on Twitter: "Many thanks to @StuartAndrew for standing in for me at business questions.
Photo by: zz/KGC-107/STAR MAX/IPx 2020 3/9/20 Jacob Rees-Mogg attends the Commonwealth Day Service at Westminster Abbey. (London, England, UK)
Leader of the House of Commons Jacob Rees-Mogg walks through through the Sovereign's entrance for the State Opening of Parliament by Queen Elizabeth II, in the House of Lords at the Palace of Westminster in London, Thursday Dec. 19, 2019. (Victoria Jones, Pool via AP)
Britain's Leader of the House of Commons, Conservative MP Jacob Rees-Mogg smiles as he walks through Peers' Lobby ahead of the State Opening of Parliament at the Houses of Parliament in London, Thursday, Dec. 19, 2019. Britain's Queen Elizabeth II will formally open a new session of Britain's Parliament on Thursday, with a speech giving the first concrete details of what Prime Minister Boris Johnson plans to do with his commanding House of Commons majority. (Hannah McKay/Pool Photo via AP)
Leader of the House of Commons Jacob Rees-Mogg speaks with guests in the chamber ahead of the State Opening of Parliament by Queen Elizabeth II, in the House of Lords at the Palace of Westminster in London, Thursday Dec. 19, 2019. (Aaron Chown, Pool via AP)
A heavy police presence escorts Leader of Britain's House of Commons Jacob Rees-Mogg from parliament in London, following a Brexit debate Saturday Oct. 19, 2019. Many thousands of protesters gathered in London to demonstrate on both sides of the Brexit argument. (Jacob King/PA via AP)
Britain's Leader of the House of Commons Jacob Rees-Mogg laughs whilst talking with someone before the arrival of Britain's Queen Elizabeth II in the Norman Porch at the Palace of Westminster and the Houses of Parliament for the State Opening of Parliament ceremony in London, Monday, Oct. 14, 2019. (AP Photo/Matt Dunham, Pool)
Jacob Rees-Mogg, Leader of the House of Commons, addresses the media at the Conservative Party Conference in Manchester, England, Monday, Sept. 30, 2019. Prime Minister Boris Johnson has vowed that Britain will leave the European Union on the scheduled date of Oct. 31, with or without a divorce deal governing future relations with the bloc. (AP Photo/Frank Augstein)
Leader of Britain's government the House of Commons Jacob Rees-Mogg speaking at the annual Conservative Party Conference in Manchester, England, Sunday Sept. 29, 2019. The Conservative Party is committed to Britain's Brexit split from the European Union leaving on the scheduled date of Oct. 31.(Danny Lawson/PA via AP)
Britain's Leader of the House of Commons Jacob Rees-Mogg reclines on his seat in the House of Commons, London, Tuesday Sept. 3, 2019. With Britain's prime minister Boris Johnson weakened by a major defeat in Parliament, defiant lawmakers were moving Wednesday to bar him from pursuing a "no-deal" departure from the European Union.(Parliament TV via AP)
British lawmaker Jacob Rees-Mogg poses for a photograph prior to speaking at a meeting for eurosceptic think tank The Bruges group, in London, Wednesday, Jan. 23, 2019. (AP Photo/Alastair Grant)
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"One of my children was tested for Covid-19 last weekend after displaying symptoms.
"In accordance with Government guidance, the household has been in self-isolation while we await the test result."
Explaining the minister's absence to MPs, Mr Andrew said: "A member of the Leader of the House's household is awaiting a Covid test result after having been symptomatic.
"The leader is therefore self-isolating along with his family."
A spokesman for Mr Rees-Mogg said no further details would be provided on the matter.
Mr Rees-Mogg last week tweeted a photo of five of his children dressed in their uniforms as they returned to school.
He wrote at the time: "The holidays are over and my five older children certainly need and want to be at school."
For Labour, shadow Commons leader Valerie Vaz told MPs: "We all wish the Leader of the House and the whole Rees-Mogg family well, and we know it had to be something very, very serious for him not to be here."
SNP Commons leader Tommy Sheppard joked that he would miss being "patronised in the flesh" by Mr Rees-Mogg.
The MP for Edinburgh East has contributed remotely to proceedings on several occasions during the coronavirus pandemic.
Mr Sheppard told the Commons: "Can I also wish the Leader of the House and his family well. I can hardly hide my disappointment at his absence.
"After five long months of my own absence from this chamber, and sometimes problematic communication through the virtual proceedings, I have been looking forward to being patronised in the flesh rather than over the internet."