Thousands offer to help in Covid-19 blood plasma trial

Around 6,000 people who have recovered from Covid-19 have signed up to donate their blood plasma to see if it can help patients currently infected with the virus.

A call from the NHS for patients to come forward has led to around 6,000 registrants who tested positive for coronavirus, including more than 500 people who were admitted to hospital.

Some have now begun donating their blood plasma in a process known as plasmapheresis, which uses a machine similar to that used in regular blood platelet donation.

Donating plasma
Recovered coronavirus patient Douglas James donating convalescent plasma by plasmapheresis at Tooting Blood Donor Centre, London (Kirsty Hamilton/NHSBT/PA)

The plasma from former patients is rich in the antibodies that develop as somebody recovers from an illness.

It will be transfused into people who are seriously ill with Covid-19 and struggling to develop their own antibodies.

The number of antibodies rises steadily in the bloodstream of those who have been ill and is thought to peak between 21 and 28 days after recovery.

Donors must have tested positive for the illness either at home or in hospital, but should now be three to four weeks into their recovery – ideally 29 days.

We’re leading a major programme to collect plasma from people who've recovered from #COVID19.

This is to support a clinical trial to determine if plasma from recovered patients can help those battling the illness.

Find out more: https://t.co/9P7AyjGYylpic.twitter.com/uMTNkltZrU

— NHS Blood+Transplant (@NHSBT) April 26, 2020

A donation session takes around 45 minutes to give two units of plasma, and can be repeated as regularly as every fortnight.

Previous research has suggested that antibodies drawn from the blood of Covid-19 survivors improves the symptoms of patients severely ill with the disease.

Scientists in China who carried out the preliminary study said no serious adverse reactions were observed after convalescent plasma transfusion.

Ten patients received a 200ml dose of plasma, and researchers said all clinical symptoms, which also included fever and cough, subsided within three days.

Coronavirus – Sat Apr 25, 2020
Michael Squire, 30, is one of the first plasmapheresis donors (NHSBT/PA)

New photos released by NHS Blood and Transplant (NHSBT) were taken at the Tooting Blood Donor Centre in London over the weekend.

The first plasmapheresis donations started last week.

Plasma donations will initially be used in a clinical trial.

However, more plasma is being collected than is needed so that, if the clinical trial is successful, significant quantities can be supplied to hospitals immediately.

An NHS Blood and Transplant spokesman said: “This trial is world-leading research and these people are leading the way.

“Plasma donation is safe and easy and you could help save the lives of others with coronavirus.

“We recognise some donors will have had a difficult experience and we will make everyone feel cared for and welcome.

“We’re so grateful to everyone who wants to donate to try and help us to beat this pandemic.”

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