UK researchers screening volunteers for coronavirus vaccine trial

Researchers in the UK have started screening healthy volunteers for an upcoming coronavirus vaccine trial.

University of Oxford scientists are recruiting 18-55-year-olds for the trial in the Thames Valley region.

The vaccine is already in production but will not be ready for a number of weeks.

The trial will provide information on the safety aspects of the vaccine, as well as its ability to generate an immune response against the virus.

It will recruit up to 510 volunteers, who will receive either the ChAdOx1 nCoV-19 vaccine or a control injection for comparison.

Participants are not expected to receive the vaccine for some weeks, and in the meantime preclinical work is being done and the vaccine is being manufactured to clinical grade standard at the Clinical Biomanufacturing Facility at Oxford University.

The trial has been approved by UK regulators and ethical reviewers.

Scientists are working as quickly as possible to get the vaccine trial ready, which includes further preclinical investigations and production of a larger number of doses of the vaccine.

Professor Adrian Hill, director of the Jenner Institute at the University of Oxford, said: "The Oxford team had exceptional experience of a rapid vaccine response, such as to the Ebola outbreak in West Africa in 2014.

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Britain before and after coronavirus lockdown
A composite image of the streets in the centre of Bath busy with visitors and shoppers on 11/03/20 (top) and the empty streets on Tuesday 24/03/20 the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
Composite photos of Bournemouth beach on 28/06/19 (top), and on Monday 23/03/20 (bottom), the day Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
Composite photos of London's National Gallery in Trafalgar Square on 28/01/14 (top), and on Tuesday 24/03/20 (bottom), the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
A composite image of London's Canary Wharf Jubilee Line platform on 31/01/13 (top), and on Tuesday 24/03/20 (bottom), the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
Composite photos of London's Tower Bridge on 16/03/20 (top), and on Tuesday 24/03/20 (bottom), the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
A composite image of commuters at Waterloo station in London on 12/03/20 (top), and on Wednesday 25/03/20 (bottom), after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
Composite photos of ticket holders for Comedy about a Bank Robbery in line outside the Criterion Theatre, London on 12/03/20 (top), and the theatre on Tuesday 24/03/20 (bottom), the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
A composite image of of commuters crossing London Bridge on 13/03/20 (top), and on Wednesday 25/03/20 (bottom), after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
Composite photos of London's Buckingham Palace during the Changing of the Guard on 13/03/20 (top), and on Tuesday 24/03/20 (bottom), the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
Composite photos of Bournemouth beach on 14/09/19 (top), and on Monday 23/03/20 (bottom), the day Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
A composite image of people walking across the Millennium Bridge, London, with St Paul's Cathedral in the background, on 13/03/20 (top), and on Wednesday 25/03/20 (bottom), after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
A composite image of London's Canary Wharf Station on 17/03/20 (top), and on Tuesday 24/03/20 (bottom), the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
Composite photos of ticket holders for Harry Potter and the Cursed Child in line outside the Palace Theatre, London on 12/03/20 (top), and the theatre on Tuesday 24/03/20 (bottom), the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
A composite image of London's Canary Wharf Station on 17/03/20 (top), and on Tuesday 24/03/20 (bottom), the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
A composite image of the streets in the centre of Bath busy with visitors and shoppers on 11/03/20 (top) and the empty streets on Tuesday 24/03/20 the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
A composite image of visitors to Leicester Square, London, on 13/03/20 (top), and on Wednesday 25/03/20, (bottom), after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
Composite photos of ticket holders for Ticket holders for Come from Away in line outside the Phoenix Theatre, London on 12/03/20 (top), and the theatre on Tuesday 24/03/20 (bottom), the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
A composite image of the streets in the centre of Bath busy with visitors and shoppers on 11/03/20 (top) and the empty streets on Tuesday 24/03/20 the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
Composite photos of Edinburgh's Royal Mile on 14/03/20, and on Saturday (21/03/20) after bars, pubs and restaurants were instructed to close. Prime Minister Boris Johnson put the UK in lockdown on Monday night to help curb the spread of the coronavirus.
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Composite photos of people on the beach at Barry Island, South Wales, on 19/06/17 (top), and on Wednesday 25/03/20 (bottom), after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
A composite image of the streets in the centre of Bath busy with visitors and shoppers on 11/03/20 (top) and the empty streets on Tuesday 24/03/20 the day after Prime Minister Boris Johnson put the UK in lockdown to help curb the spread of the coronavirus.
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"This is an even greater challenge.

"Vaccines are being designed from scratch and progressed at an unprecedented rate.

"The upcoming trial will be critical for assessing the feasibility of vaccination against Covid-19 and could lead to early deployment."

At the same time as conducting the first clinical trial, production of the vaccine is being scaled up ready for larger trials, and potentially, future deployment as soon as possible.

HEALTH Coronavirus
(PA Graphics)

Dr Sandy Douglas, who is leading on the vaccine manufacturing scale-up project, said: "The scale of this epidemic poses a huge challenge for vaccine manufacturing.

"We need to follow rigorous safety standards and that takes time.

"By starting work on large-scale manufacturing immediately, we hope to accelerate the availability of a high-quality, safe vaccine."

The particular vaccine being tested was chosen because it can generate a strong immune response from one dose and it is not a replicating virus, so it cannot cause an ongoing infection in the vaccinated individual.

This also makes it safer to give to children, the elderly and anyone with a pre-existing condition such as diabetes.

People interested in volunteering can find more information on the Covid-19 vaccine website.

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