A third patient has died in the UK after testing positive for coronavirus, chief medical officer Professor Chris Whitty said.
The man, aged in his 60s, who had underlying health problems, died at North Manchester General Hospital having recently returned from Italy.
A spokesman for the hospital said: "We can confirm that sadly a patient being treated for Covid-19 has died at our specialist regional Infectious Diseases unit at North Manchester General Hospital.
"The man in his sixties tested positive after travelling to Italy and had a number of underlying health problems.
"Our thoughts are with the patient's family who are being supported by our specialist bereavement staff."
Prof Whitty said: "I am very sorry to report that a third patient in England who tested positive for Covid-19 has sadly died.
"I offer my sincere condolences to their family and friends and ask that their privacy is respected."
He said that contact tracing was already under way.
The announcement of the death follows confirmation on Friday that an 83-year-old great-grandfather had become the second person to die in the UK after testing positive for coronavirus.
The man, who also had underlying health conditions, died on Thursday while being treated at Milton Keynes University Hospital.
His family paid tribute to him as a "truly loving and wonderful person".
On Thursday evening, another patient, reported to be a woman in her 70s, became the first person in the UK to die after being diagnosed with Covid-19, while at the Royal Berkshire Hospital in Reading.
More than 270 people have now tested positive for coronavirus in the UK, the Department of Health has said.
As of 9am on Sunday, 273 people had been diagnosed with Covid-19 – an increase of 67 from the 206 cases confirmed at 7am on Saturday.
It represents the largest day-on-day increase in diagnoses.
More than 23,500 people have been tested for the virus in the UK, with two patients with Covid-19 having died.
Two more cases have been confirmed in Scotland, bringing the total there to 18.
On Saturday night, three more people were diagnosed in Northern Ireland pushing its total to seven, while on Sunday morning it was announced confirmed cases in Wales had risen from two to four.
Supermarkets have started placing restrictions on items including pasta, anti-bacterial wipes and hand soap in a bid to prevent shoppers from stockpiling.
Commenting on reports of people panic-buying in shops, Prime Minister Boris Johnson said on Sunday: "We've had no advice from the scientific advisers or medical officers that there's any need for people to buy stuff in.
"If you think you have symptoms, the best thing to do as you know is to stay at home and contact the NHS.
"We will make sure we give the NHS... the investment it needs to cope with this crisis."
The latest coronavirus figures were published as Health Secretary Matt Hancock said a "national effort" is required to tackle the outbreak.
He hailed the "good example" set by a group of people released from hospital quarantine on Sunday, who had been repatriated to the UK last month from the coronavirus-hit Diamond Princess cruise ship in Japan.
The group of 30 Britons and two Irish nationals are now allowed to leave Arrowe Park hospital in the Wirral, having been given the all-clear from infection.
Mr Hancock said: "Tackling coronavirus is a national effort and they have set a good example for the rest of the public as more people may need to self-isolate themselves at home.
"Public safety is our top priority and we all have a part to play in containing the spread of the virus."
Meanwhile in Italy, more than a quarter of population has been placed in mandatory quarantine as the Government attempts to stem the spread of the coronavirus.
One unnamed man diagnosed with coronavirus in the UK told BBC Radio 4 he was "shocked" and "surprised" at the lack of coronavirus information when he arrived at Manchester Airport after a skiing holiday in northern Italy last weekend.
Immediately self-isolating at home with his wife, he said the experience of being tested was "frightening" but was now feeling "well recovered" as he waited for a further test.
"By self-isolating think of all the lives we've saved," he said.
Mr Hancock has set out plans contained in emergency legislation to deal with the impact of the virus.
The Bill, which is likely to go through Parliament by the end of the month, is expected to include measures to allow some court proceedings to be conducted via telephone or video.
Volunteers will be given additional employment safeguards, allowing them to leave their main jobs and temporarily help health and social systems in the event of a widespread pandemic.
The chairman of the Royal College of GPs, Professor Martin Marshall, told Sky's Sophy Ridge on Sunday that tackling coronavirus will likely lead to hospitals having to cut down on "other work".
He also said he expected retired doctors and other medical professionals to answer the Government's call to assist with the crisis.
"Most likely these doctors, because they are in the higher risk patient group, would not do face-to-face contact but there's lots of things they can do – managing 111, providing online care or telephone-based care," he said.
Dr Margaret Harris, from the World Health Organisation, speaking on the BBC's Andrew Marr Show, said supporting health workers with training and equipment should be the "number one priority".
She added: "And they need back-up, they need other people to come and do the shifts. If they're working massively, they are tremendously at risk."
She also highlighted the British Army's experience in setting up field hospitals, suggesting it should be factored in to coronavirus planning.
The Chancellor, Rishi Sunak, preparing to deliver his first Budget, said on Sunday the Government was ready to deliver "whatever action is required" to deal with the crisis.
On Monday, Mr Johnson will chair a meeting of the Government's emergency committee, Cobra, while sports governing bodies and broadcasters will attend a meeting with the Department for Digital, Culture, Media and Sport to discuss how to handle the outbreak's possible impact on the sporting calendar.
Speaker Sir Lindsay Hoyle will chair a meeting of the House of Commons Commission to discuss Parliament's response.
Environment Secretary George Eustice will hold further talks with retailers to discuss support for vulnerable groups who may have to self-isolate.