More journeys affected amid a bombardment of snow and cold weather.
Several road closures are in force, while trains and flights have been hit by delays and cancellations.
Here are some of the latest reported issues.
Drivers were urged by transport authorities to consider whether they needed to embark on journeys after a number of people became stranded.
Police Scotland warned people not to travel unless they were an emergency worker.
By 5pm on Thursday, the RAC had attended 8,000 breakdowns across the UK - which was 70% more than expected in early March.
The worst hit region was the West Midlands, where the number of call outs was double the normal rate for this time of year.
An RAC spokesman said: "As well as towing members out of snowdrifts, our patrols have also seen a lot of other problems that tend to only come up in the extreme cold - such as frozen washer bottles and frozen diesel fuel lines, plus blown fuses and wiper motors after windscreen wipers have stuck to windscreens."
Lincolnshire Police warned that the A52 was "impassable" between Boston and Skegness due to drifting snow, and warned that drivers faced becoming stranded.
"We are not in a position to recover you," the force tweeted.
The fire and rescue service added that even a snowplough was unable to get through to clear the route.
Several other roads in Lincolnshire have also been shut, including the A17 and the A15 between the M180 and Lincoln.
Cheshire Police said there were around eight miles of tailbacks on the M62 as officers with 4x4s, Highways England patrols, contractors and snowploughs attempted to clear snow between junctions 21 and 22 eastbound.
The A66 in Cumbria was closed in both directions between Scotch Corner and Brough due to "severe snowfall", while the A56 in Lancashire was likely to be closed for "several hours" due to a lorry crash between the M65 and A680.
Northumbria Police said the A68 was closed between Corbridge and Ridsdale.
In Derbyshire, the Woodhead Pass was shut in both directions between Tintwistle and Flouch.
Nearly all train operators across the UK suffered cancellations and disruption on Thursday.
All cross-border trains between England and Scotland were suspended.
The West Coast Main Line was closed between Carlisle and Scotland, with no trains or replacement buses.
Virgin Trains East Coast asked passengers "not to travel" on Thursday or Friday across the entire East Coast Main Line between London and Scotland.
ScotRail also advised passengers not to board trains and ended services early on Thursday.
London Paddington, the UK's seventh busiest station, was closed for several hours from 8am, meaning long distance services had to start and terminate at Reading.
Around 50 stations in Kent and East Sussex were closed on Thursday as operator Southeastern advised commuters to work from home if possible.
Northern said the severe weather left several routes blocked, with delays and cancellations across the whole network.
Flight schedules are being decimated by the severely cold weather.
More than 4,000 flights have been cancelled across Europe since Tuesday.
The world's busiest two-runway airport, Heathrow, saw 329 departing or arriving flights cancelled on Thursday, representing a quarter of all scheduled services.
Airlines cut flights following discussions with airport bosses and air traffic control provider Nats.
A further 195 flights on Friday have already been cancelled in a bid to give passengers as much notice as possible.
Dublin Airport suffered 266 cancellations, with airlines such as Ryanair suspending flights.
Glasgow Airport was shut for the second day in a row, meaning 204 flights were cancelled on Thursday.
Other airlines with large numbers of cancellations include Edinburgh (244), London City (139), Gatwick (138) and Bristol (95).