The initiative is the result of a collaboration between the Royal Mint and the National Trust, to celebrate 375 years since his birth.
The Mint also plans to release more of the coins into circulation across the country in the coming months.
However, the batch of coins released at Woolsthorpe Manor could turn out to be quite desirable among collectors due to their 2017 date.
Anne Jessopp, the Royal Mint's director of consumer coin, said: "As well as undertaking pioneering work in the fields of physics and astronomy - work for which he is widely known - Isaac Newton was also master of the Royal Mint for three decades, so we couldn't think of a better place to issue a special release of these coins than Woolsthorpe Manor, Newton's birthplace."
Commemorative editions of the coins in gold, silver and collectable brilliant uncirculated finishes are also available to buy from the gift shop at Woolsthorpe Manor, as well as directly from the Royal Mint website.
As well as helping to shape our understanding of maths and physics, Sir Isaac was master of the Royal Mint for nearly three decades.
When he was appointed warden of the Mint in 1696, at the age of 53, he was already a well-established scientist.
A report he produced in 1717 helped to establish gold coin as the pre-eminent currency of the UK, paving the way for the introduction of the "gold standard".
The 50p coin has been designed by Aaron West, one of the Mint's team of graphic designers.
Jannette Warrener, operations manager at Woolsthorpe Manor, National Trust, said: "This is the perfect way to celebrate the 375th anniversary of Isaac Newton.
"We are forging a link between two of the places that played an important role in his life - Woolsthorpe Manor, where he was born but also where he achieved some his most notable and world-changing scientific thinking, and the Royal Mint, where he spent much of his working life."
Incredibly valuable coins
Incredibly valuable coins
This Australian coin was the first half crown minted under Edward VII. The price for a Melbourne coin in good condition is particularly high because around half of them were produced with faults. It’s now worth £7,500 and has risen in value some 13,789% since it was first in production
The only half crown on the list gets its position from its rarity value. However, the fact this is a silver coin rather than a gold one does affect its value - so it’s worth £10,500. It’s significantly less than others on the list - but it has still appreciated 79,445%.
This is the newest coin in the top ten, and the first year that sovereigns were produced featuring the Queen. The coin was produced in small numbers for investors - rather than for circulation - so is thought to be worth £12,500, due to its rarity.
This is another collectable gold coin prized for its rarity value. It’s worth £15,000 today and has appreciated 191,716%
This was issued in very small numbers, as it was produced during WWI. As a result, few are available - especially as uncirculated coins - so one in good condition will fetch £16,000.
This is another coin prized for its rarity, thanks to a relatively low number being minted, and more being taken out of circulation during WWI. It’s now thought to be worth £17,000 after appreciation of 42,084%.
This 1926 coin has shot up in value and is now worth £31,500. The rise in value is partly to do with a very low mintage, and partly to do with the fact that people were asked to hand their sovereigns over to be melted down during WWI, which took many of them out of circulation.
This brass threepence from 1937 has benefited enormously from the fact that Edward didn’t stick around for long to get too many coins struck in his image before he abdicated. It is now worth £45,000.
This 1933 penny has seen a stunning appreciation in value and is valued at a whopping £72,000 today. The value is due entirely to rarity. Only around seven British versions of this coin were minted, and were intended for the King to bury under the foundation stones of new buildings. They have been subject to theft, and a few are said to be in private hands now.
This isn’t the oldest coin in the list, but it was produced in a year when all gold coins were recalled and exchanged for paper money - so the vast majority were melted down. Its rarity and popularity puts it head and shoulders above the rest. It is worth an eye-watering £6,500,000, and has increased in value 2,178,885% since it was produced.