Barack Obama has joked that Prince George's dressing gown reception was a "slap in the face" as it hinted he is on the way out of office.
The young Prince's informal attire during the Obamas visit to the UK last month showed "some foreign leaders are looking ahead", the outgoing president mused at the White House Correspondents' Dinner, jesting that it was a "clear breach of protocol".
It was the final time Obama addressed the star-studded event, which traditionally sees the president deliver a speech in which they poke fun at themselves and others.
The Queen, David Cameron and Shakespeare provided material for the witty set, which was executed with the masterful skill expected from an orator with eight years' experience as a global leader.
Images of the Prince meeting the president and wife Michelle in his pyjamas were broadcast around the world after the couple spent an evening with the Duke and Duchess of Cambridge at Kensington Palace during their official visit.
Obama described George, two, as "adorable" during the trip, but reflecting on the moment during his speech on Saturday he suggested light-heartedly that the young royal's attire held much broader significance.
He quipped to laughter that being greeted by George in his checked pyjamas and monogrammed bathrobe was a slight akin to Republican leaders no longer answering his phone calls, a sign attention is elsewhere as he prepares to leave office later this year.
He said: "It's not just Congress. Even some foreign leaders they have been looking ahead, anticipating my departure.
"Last week Prince George showed up to our meeting in his bath robe. That was a slap in the face. A clear breach of protocol."
The Prince was allowed to stay up late to meet the president and first lady, who he showed the rocking horse they gave to him when he was born.
During the trip in April, the Obamas met the Queen and the Duke of Edinburgh, Prime Minister David Cameron, who played golf with Mr Obama, and visited Shakespeare's Globe.
The occasions provided material for another pithy gag by the beaming African American leader.
He said: "While in England I did have lunch with Her Majesty the Queen, took in a performance of Shakespeare, hit the links with David Cameron.
"Just in case anybody is still debating whether I am black or not, I think that settles the debate."
British actors Dame Helen Mirren, Emma Watson and Tom Hiddleston were among the guests seen mingling with Hollywood stars on the red carpet ahead of the dinner attended by Jared Leto, Will Smith, Rachel McAdams and Jeff Goldbloom.
Dame Helen received a special, if brief, mention in the President's speech. He said: "I don't have a joke here - I just think Helen Mirren is awesome."
Democratic presidential candidate Bernie Sanders, vice president Joe Biden, secretary of state John Kerry and former New York mayor Michael Bloomberg were among the political big-hitters to turn out for Obama's final appearance at the event.