The flat where Madeleine was last seen in 2007 had been on sale for £255,000 - around £50,000 less than identical properties in the area.
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But it has now reportedly been bought by British widow Kathleen Macguire-Cotton, who paid just £113,000 for the holiday pad.
Madeleine was just three-years-old when she disappeared without a trace as her parents, Kate and Gerry, dined in a nearby tapas restaurant in the resort of Praia da Luz.
They were on holiday with Madeleine and their two other children at the time.
Madeleine vanished without a trace in May 2007
Mrs Macguire-Cotton, in her 60s, is reported to have bought apartment 5A in the Ocean Complex several years ago, but does not advertise it as a holiday let like its previous owners, according to The Sun.
The gran, from Southport, Merseyside, said she had turned down offers from snoopers to look inside flat where the toddler was last seen.
The family were staying in the Ocean Complex in Praia Da Luz when Madeleine disappeared
It was recently revealed how "ghoulish" Madeleine McCann tours around the resort were being offered and participants were even invited to speculate about the toddler's fate.
Mrs Macguire-Cotton told the newspaper : "I've been offered money by the whole world but I'm not interested. I don't think that's very fair to the McCann family or the people of Praia da Luz, upsetting everybody – it's terrible.
"It happened a long time ago and I don't have any opinions on it."
The previous owner, Ruth McCann, no relation to the family, struggled to sell that flat for a long time because of its sinister history.
Madeleine's parents and British police believe she was snatched either by burglars or child traffickers.
GP Kate and cardiologist Gerry have recently been locked in legal fights in Portugal.
Their "arguido" status - which literally translates as "suspect" - was lifted by the country's highest court.
Kate and Gerry McCann lost their libel battle against a Portuguese detective who wrote a book about the case
In a complaint lodged with Portugal's Supreme Court, their lawyer Isabel Duarte said: "There is no evidence they have committed any crime."
It came after the court ruled against them in a libel battle with ex-police chief Goncalo Amaral, who led the probe after Madeleine vanished in 2007.
Amaral, 57, had been ordered to pay the McCanns £360,000 in damages for shocking claims he made about them in his book, The Truth of the Lie, but the ruling was overturned last April.
The judges said he did not act with "defamatory intention" but was making a judgment on available evidence.
Now the couple, both 48, face having to pay his legal bills and he could even sue them.